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Programma 2022

vrijdag 21 jan

12:55

Opening

Parallel track 1

13:00

Combo IO-CT in NSCLC in stage IV

Prof. Dr. Martin Reck, pulmonologist, Lungenclinic

Biografie
Martin Reck, MD, PhD, is head of the Department of Thoracic Oncology and head of the Clinical Trial Department in the Department of Thoracic Oncology at the Lung Clinic Grosshansdorf, Germany.
He is also Principal Investigator in the Airway Research Center North (ARCN), which is a member of the German Centre for Lung Research (DZL).
Dr Reck has been a Principal Investigator (PI) in various clinical trials since 1993. His main interests are new medical treatments of thoracic malignancies as well as translational research related to predictive markers. A particular focus of his work has been attributed to the clinical development of antiangiogenic compounds. Recently he also has been deeply involved in several key trials with immunotherapies including ipilimumab, PD-1 and PDL-1 antibodies and other agents. As part of this activity he has been the principal investigator of the Keynote 24 trial investigating monotherapy with Pembrolizumab against platinum based chemotherapy in untreated patients with advanced PDL-1 expressing NSCLC (TPS =/> 50%), IMpower 150 trial and the CheckMate 9LA trial, which evaluated the combination of Nivolumab and Ipilimumab together with a short chemotherapy. Furthermore he has served on various Global Trial Steering Committees.
Besides the European Society of Medical Oncology (ESMO) Dr Reck is member of the International Association for the study of Lung Cancer (IASLC), the American society of Medical Oncology (ASCO), the German Working Group for Lung Cancer, the German Cancer Society (DKG) and the German Society of Pulmonology (DGP).
He has published papers in numerous peer-reviewed journals and is member of the editorial board of Journal of Thoracic Oncology, Annals of Oncology and Lung Cancer.

Samenvatting presentatie
The implementation of immunotherapies has significantly improved our opportunities to treat non oncogenic driven advanced non-small cell lung cancer (NSCLC). I will discuss the most recent data for the novel opportunity to use double immunotherapy combinations as first-line treatment.

9-Reck-Martin

13:25

Therapeutic options after first-line triple therapy

Prof. Fabrice Barlesi, pulmonologist, Gustave Roussy

Biografie
Le Pr Fabrice Barlesi est Directeur Général au sein de l’institut Gustave Roussy. C’est un des acteurs majeurs de la recherche sur les thérapies innovantes contre le cancer.
Il a cofondé le cluster français de l’immunologie Marseille Immunopôle dont la mission est de rassembler les expertises en immunologie de la métropole d’Aix-Marseille.
Le Pr Barlesi est auteur et co-auteur de près de 400 publications parues dans des revues internationales ou des ouvrages spécialisés.
En 2018, la Société européenne d’oncologie médicale (ESMO) et l’Association internationale pour l’étude du cancer du poumon (IASLC) lui ont décerné le prestigieux prix Heine H. Hansen.
Fabrice Barlesi figure dans la liste des chercheurs les plus influents au monde (Highly cited researchers de Web of Science Group).

10-Barlesi-Fabrice

13:50

IO therapy beyond PD-(L)1

Prof. Dr. John Haanen, medisch-oncologist, Antoni Van Leeuwenhoek Ziekenhuis

Biografie
John Haanen finished is MD at Leiden University cum laude in 1988. From 1988 till 1991 he performed his PhD studies at the Division of Immunohematology & Blood Bank of Leiden University Medical Center and at DNAX, Research Institute, Palo Alto, California, US and defended his PhD thesis on human CD4+ helper T cells reactive against mycobacteria. He trained in internal medicine in hospitals in Leiden and The Hague. In 1996 he was registered as consultant internist. From 1997-1999 he did a post-doctoral fellowship at the Division of Immunology of the Netherlands Cancer Institute (NKI), Amsterdam. From 1999-2001 he trained in medical oncology and was appointed a permanent position as consultant medical oncologist and research group leader at NKI. His research has been focused on development of innovative immunotherapies in close collaboration with prof. Ton Schumacher. In 2008 he was appointed professor of translational immunotherapy of cancer at Leiden University Medical Center. From 2009 till 2018 he headed the Division of Medical Oncology at NKI. In 2018 he was appointed CSO Immunotherapy, one of the major research themes at NKI. His current research is on development of cellular therapies for solid tumors, neoadjuvant immunotherapies, and biomarker research. His clinical specialty is in melanoma and other skin cancers, kidney cancer and management of immune-related adverse events. He co-authored over 300 peer-reviewed articles, serves at the editorial board of ESMO Open, Cancer Treatment Reviews and Kidney Cancer. He is currently Editor-in-Chief of ESMO IOTECH. John Haanen was scientific co-chair of ESMO IO Congress from 2016-2019, and Scientific Chair of the ESMO 2020 Congress.

Samenvatting presentatie
In my lecture on immunotherapy beyond anti-PD-(L)1, I will mainly focus on 3 subjects. Novel combinations with immune checkpoint inhibitors, treatment of earlier stages of NSCLC and the introduction of cell therapies. For more details on the latter, I refer to the presentation of Dr S. klobuch from NKI.

4-Haanen-John

14:15

Q&A

Parallel track 2

13:00

EGFR, ALK and KRAS

Dr. Pasi Janne, oncologist, Dana-farber Cancer institute

13:50

Antibody-drug conjugates in 2022

Prof. Dr. Egbert Smit, longarts, LUMC

14:15

Q&A

Parallel track 1

14:30

Neo-adjuvant therapies in resectable stages

Prof. Dr. Martin Schuler, Director Department Of Medical Oncology, University Hospital Essen

Biografie
Professor Schuler is board certified in internal medicine, hematology/medical oncology, pulmonary medicine, and palliative medicine. He is a member of several professional associations, including the German Society of Hematology and Oncology, the German Society of Pulmonary Medicine, the American Society of Clinical Oncology, and the International Association for the Study of Lung Cancer. Professor Schuler sits on the editorial boards of several scientific journals, including Oncogene, the Journal of Cancer Research and Clinical Oncology, and Oncology Research and Treatment. He has authored or co-authored more than 100 original articles published in peer-reviewed journals such as Cancer Cell, Science, Nature, the New England Journal of Medicine, Lancet Oncology and the Journal of Clinical Oncology. Professor Schuler has received several awards including the AIO Scientific Award of the German Cancer Society and the Pulmedica Award of the German Society for Pulmonary and Respiratory Research.

7-Schuler-Martin

14:55

IO strategies in unresectable stage III NSCLC

Dr. Willemijn Theelen, longarts, Antoni van Leeuwenhoek Ziekenhuis

15:20

Vaccines for lung cancer

Prof. Dr. Joachim Aerts, longarts, Erasmus MC

Biografie
Joachim Aerts is head of the department of Pulmonary Medicine at the Erasmus University Medical Center Rotterdam since 2018. His main research focus is on fundamental, translational and clinical research in immuno oncology, with a strong focus on lung cancer and mesothelioma. As PI and as co-investigator, prof. Aerts is involved in many studies both human and animal.

Prof. Aerts is leader of the core network on mesothelioma and board member of the European Reference Network on Rare Respiratory Diseases (ERN-Lung) and elected member of the board of directors of the International Association for the Study of Lung Cancer (IASLC). He is a frequent invited speaker on international conferences, and he is scientific committee member of multiple national and international societies, such as the NVALT, EORTC, ASCO, ESMO, ETOP, AACR, ERS and ATS. Prof. Aerts is co-author of >200 articles in international peer reviewed scientific journals.

 

2-Aerts-Joachim

15:45

CAR-T cells

Dr. Sebastian Klobuch, medisch oncoloog, Antoni Van Leeuwenhoek Ziekenhuis

16:10

Q&A

Parallel track 2

14:30

How to find these drivers in tumor tissue and ctDNA

Prof. Dr. Michel van den Heuvel, longarts, RadboudUMC

14:55

How to set up a Molecular Tumor Board

Prof. Sanjay Popat, medical oncologist, Royal Marsden Hospital

15:20

Genetic disarrangements in MPM

Prof. Aaron Mansfield, researcher, Mayo Clinic

Biografie
Dr. Mansfield is a medical oncologist at Mayo Clinic with a focus on thoracic malignancies and early therapeutics. He is co-director of the Precision Cancer Therapeutics group within the Center for Individualized Medicine. His laboratory runs many translational projects to discover and validate biomarkers in thoracic malignancies.

Samenvatting presentatie
Tumor junction burden as a predictor of survival with immunotherapy in mesothelioma

94-Mansfield-Aaron

15:45

MPM treatment in the IO era

Dr. Sjaak Burgers, longarts, Antoni van Leeuwenhoek Ziekenhuis

16:10

Q&A

Time to switch track

Parallel track 1

16:20

Medical Cross Fire: stage IV with PD-L1 >50%

Michel van den Heuvel & Fabrice Barlesi

Michel van den Heuvel IO monotherapy is 1st choice (7m)
Fabrice Barlesi Chemo-IO is 1st choice (7 m)

Parallel track 2

16:20

Medical Cross Fire: MET exon 14 skipping mutations:

Egbert Smit & Pasi Janne

Egbert Smit Chemotherapy is 1st choice (7m)
Pasi Janne Targeted agents are 1st choice (7m)

17:00

Vera Bonta Award

17:20

Closing